Epidural Spinal Cord Stimulation

Epidural spinal cord stimulation (eSCS) is an invasive treatment aimed at stimulating spinal circuits to control various physiological functions. There are several prominent examples, including lumbosacral eSCS to facilitate lower limb motor function. Despite significant progress in understanding eSCS interactions with the nervous system, many questions remain. Different eSCS treatment modalities have emerged, each with varying patient outcomes; some show high clinical efficacy but face challenges for widespread adoption.

To support therapy design, verification, and clinical decision-making, we are developing methods to efficiently create multi-scale digital twins of the spinal cord. Our focus is on efficiently exploring high-dimensional parameter spaces to find Pareto-optimal solutions that balance potentially conflicting goals.

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First Published on September 23, 2024
Last Updated on October 7, 2024 by Vincent Gemar