Publications
Publications
2025
5204873
GWZUDZFB
2025
1
modern-language-association
50
date
desc
84
https://www.pdh.med.fau.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%2288W9IF2L%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Hernandez-Charpak%20et%20al.%22%2C%22parsedDate%22%3A%222025-01-23%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHernandez-Charpak%2C%20Sergio%20Daniel%2C%20et%20al.%20%26%23x201C%3BTowards%20Personalized%20Mapping%20through%20Lumbosacral%20Spinal%20Cord%20Task%20FMRI.%26%23x201D%3B%20%26lt%3Bi%26gt%3BImaging%20Neuroscience%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%203%2C%20Jan.%202025%2C%20p.%20imag_a_00455%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1162%5C%2Fimag_a_00455%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1162%5C%2Fimag_a_00455%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Towards%20personalized%20mapping%20through%20lumbosacral%20spinal%20cord%20task%20fMRI%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergio%20Daniel%22%2C%22lastName%22%3A%22Hernandez-Charpak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nawal%22%2C%22lastName%22%3A%22Kinany%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilaria%22%2C%22lastName%22%3A%22Ricchi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rapha%5Cu00eblle%22%2C%22lastName%22%3A%22Schlienger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Loan%22%2C%22lastName%22%3A%22Mattera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roberto%22%2C%22lastName%22%3A%22Martuzzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Nazarian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Demesmaeker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Kavounoudias%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dimitri%22%2C%22lastName%22%3A%22Van%20De%20Ville%22%7D%5D%2C%22abstractNote%22%3A%22The%20lumbosacral%20spinal%20cord%20contains%20neural%20circuits%20crucial%20for%20locomotion%2C%20organized%20into%20rostrocaudal%20levels%20with%20distinct%20somatosensory%20and%20motor%20neuron%20pools%20that%20project%20to%20and%20from%20the%20muscles%20of%20the%20lower%20limbs.%20However%2C%20the%20specific%20spinal%20levels%20that%20innervate%20each%20muscle%20and%20the%20locations%20of%20neuron%20pools%20vary%20significantly%20between%20individuals%2C%20presenting%20challenges%20for%20targeted%20therapies%20and%20neurosurgical%20interventions%20aimed%20at%20restoring%20locomotion.%20Non-invasive%20approaches%20to%20functionally%20map%20the%20segmental%20distribution%20of%20muscle%20innervation%5Cu2014or%20projectome%5Cu2014are%20therefore%20essential.%20Here%2C%20we%20developed%20a%20pipeline%20dedicated%20to%20record%20blood%20oxygenation%20level%20dependent%20%28BOLD%29%20signals%20in%20the%20lumbosacral%20spinal%20cord%20using%20functional%20magnetic%20resonance%20imaging%20%28fMRI%29.%20We%20assessed%20spinal%20activity%20across%20different%20conditions%20targeting%20the%20extensor%5C%2Fflexor%20muscles%20of%20the%20right%20leg%20%28ankle%2C%20knee%2C%20and%20hip%29%20in%2012%20healthy%20participants.%20To%20enhance%20clinical%20relevance%2C%20we%20included%20not%20only%20active%20movements%20but%20also%20two%20conditions%20that%20did%20not%20rely%20on%20participants%5Cu2019%20performance%3A%20passive%20stretches%20and%20muscle-specific%20tendon%20vibration%2C%20which%20activates%20proprioceptive%20afferents%20of%20the%20vibrated%20muscle.%20BOLD%20activity%20patterns%20were%20primarily%20located%20on%20the%20side%20ipsilateral%20to%20the%20movement%2C%20stretch%2C%20or%20vibration%2C%20both%20at%20the%20group%20and%20participant%20levels%2C%20indicating%20the%20BOLD%20activity%20being%20associated%20with%20the%20projectome.%20The%20fMRI-derived%20rostrocaudal%20BOLD%20activity%20patterns%20exhibited%20mixed%20alignment%20with%20expected%20innervation%20maps%20from%20invasive%20studies%2C%20varying%20by%20muscle%20and%20condition.%20While%20some%20muscles%20and%20conditions%20matched%20well%20across%20studies%2C%20others%20did%20not.%20Significant%20variability%20among%20individual%20participants%20underscores%20the%20need%20for%20personalized%20mapping%20of%20projections%20for%20targeted%20therapies%20and%20neurosurgical%20interventions.%20To%20support%20the%20interpretation%20of%20BOLD%20activity%20patterns%2C%20we%20developed%20a%20decision%20tree-based%20framework%20that%20combines%20reconstruction%20of%20neural%20structures%20from%20high-resolution%20anatomical%20MRI%20datasets%20and%20muscle-specific%20fMRI%20activity%20to%20produce%20personalized%20projectomes.%20Our%20findings%20provide%20a%20valuable%20proof-of-concept%20for%20the%20potential%20of%20fMRI%20to%20map%20the%20lumbosacral%20spinal%20cord%5Cu2019s%20functional%20organization%2C%20while%20shedding%20light%20on%20challenges%20associated%20with%20this%20endeavor.%22%2C%22date%22%3A%222025-01-23%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1162%5C%2Fimag_a_00455%22%2C%22ISSN%22%3A%222837-6056%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1162%5C%2Fimag_a_00455%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A49Z%22%7D%7D%5D%7D
Hernandez-Charpak, Sergio Daniel, et al. “Towards Personalized Mapping through Lumbosacral Spinal Cord Task FMRI.” Imaging Neuroscience, vol. 3, Jan. 2025, p. imag_a_00455, https://doi.org/10.1162/imag_a_00455.
2024
5204873
GWZUDZFB
2024
1
modern-language-association
50
date
desc
84
https://www.pdh.med.fau.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22LVG8LDFW%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Phillips%20et%20al.%22%2C%22parsedDate%22%3A%222024-11-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPhillips%2C%20Aaron%20A.%2C%20et%20al.%20%26lt%3Bi%26gt%3BThe%20Implantable%20System%20That%20Restores%20Hemodynamic%20Stability%20after%20Spinal%20Cord%20Injury%26lt%3B%5C%2Fi%26gt%3B.%20medRxiv%2C%207%20Nov.%202024%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2024.05.10.24306826%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2024.05.10.24306826%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22preprint%22%2C%22title%22%3A%22The%20implantable%20system%20that%20restores%20hemodynamic%20stability%20after%20spinal%20cord%20injury%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aaron%20A.%22%2C%22lastName%22%3A%22Phillips%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aasta%20P.%22%2C%22lastName%22%3A%22Gandhi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Hankov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergio%20D.%22%2C%22lastName%22%3A%22Hernandez-Charpak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julien%22%2C%22lastName%22%3A%22Rimok%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%22%2C%22lastName%22%3A%22Incognito%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anouk%20E.%20J.%22%2C%22lastName%22%3A%22Nijland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marina%22%2C%22lastName%22%3A%22D%5Cu2019Ercole%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Watrin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Berney%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aikaterini%22%2C%22lastName%22%3A%22Damianaki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9gory%22%2C%22lastName%22%3A%22Dumont%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicol%5Cu00f2%22%2C%22lastName%22%3A%22Macellari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%20De%22%2C%22lastName%22%3A%22Herde%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nadine%22%2C%22lastName%22%3A%22Intering%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Donovan%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryan%22%2C%22lastName%22%3A%22Miller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meagan%20N.%22%2C%22lastName%22%3A%22Smith%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordan%22%2C%22lastName%22%3A%22Lee%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edeny%22%2C%22lastName%22%3A%22Baaklini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Baptiste%22%2C%22lastName%22%3A%22Ledoux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Javier%20G.%22%2C%22lastName%22%3A%22Ordonnez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taylor%22%2C%22lastName%22%3A%22Newton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ettore%20F.%22%2C%22lastName%22%3A%22Meliad%5Cu00f2%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%5Cu00e9a%22%2C%22lastName%22%3A%22Duguet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Jacquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%5Cu00e9a%22%2C%22lastName%22%3A%22Bole-Feysot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Rieger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kristen%22%2C%22lastName%22%3A%22Gelenitis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yoann%22%2C%22lastName%22%3A%22Dumeny%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miroslav%22%2C%22lastName%22%3A%22Caban%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Damien%22%2C%22lastName%22%3A%22Ganty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edoardo%22%2C%22lastName%22%3A%22Paoles%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Baumgartner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clinical%20Study%22%2C%22lastName%22%3A%22Team%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Onward%22%2C%22lastName%22%3A%22Team%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathal%22%2C%22lastName%22%3A%22Harte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20David%22%2C%22lastName%22%3A%22Sasportes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%22%2C%22lastName%22%3A%22Romo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tristan%22%2C%22lastName%22%3A%22Vouga%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jemina%22%2C%22lastName%22%3A%22Fasola%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jimmy%22%2C%22lastName%22%3A%22Ravier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthieu%22%2C%22lastName%22%3A%22Gautier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22Merlos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rik%22%2C%22lastName%22%3A%22Buschman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tomislav%22%2C%22lastName%22%3A%22Milekovic%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22Mandija%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelis%20A.%20T.%20van%20den%22%2C%22lastName%22%3A%22Berg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niels%22%2C%22lastName%22%3A%22Kuster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esra%22%2C%22lastName%22%3A%22Neufeld%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Etienne%22%2C%22lastName%22%3A%22Pralong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenz%22%2C%22lastName%22%3A%22Hirt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22Carda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabio%22%2C%22lastName%22%3A%22Becce%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Etienne%22%2C%22lastName%22%3A%22Aleton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyle%22%2C%22lastName%22%3A%22Rogan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Patrick%22%2C%22lastName%22%3A%22Schoettker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Wuerzner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nelleke%22%2C%22lastName%22%3A%22Langerak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22No%5Cu00ebl%20L.%20W.%22%2C%22lastName%22%3A%22Keijsers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brian%20K.%22%2C%22lastName%22%3A%22Kwon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20D.%22%2C%22lastName%22%3A%22Guest%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erika%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Murphy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erkan%22%2C%22lastName%22%3A%22Kurt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steve%22%2C%22lastName%22%3A%22Casha%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fady%22%2C%22lastName%22%3A%22Girgis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilse%20van%22%2C%22lastName%22%3A%22Nes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kelly%20A.%22%2C%22lastName%22%3A%22Larkin-Kaiser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Demesmaeker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%5Cu00e9onie%22%2C%22lastName%22%3A%22Asboth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordan%20W.%22%2C%22lastName%22%3A%22Squair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22A%20spinal%20cord%20injury%20%28SCI%29%20causes%20immediate%20and%20sustained%20hemodynamic%20instability%20that%20threatens%20neurological%20recovery%20and%20impacts%20quality%20of%20life.%20Here%2C%20we%20establish%20the%20clinical%20burden%20of%20chronic%20hypotensive%20complications%20due%20to%20SCI%20in%201%2C479%20participants%2C%20and%20expose%20the%20ineffective%20treatment%20of%20these%20complications%20with%20conservative%20measures.%20To%20address%20this%20clinical%20burden%2C%20we%20developed%20a%20purpose-built%20implantable%20system%20based%20on%20biomimetic%20epidural%20electrical%20stimulation%20%28EES%29%20of%20the%20spinal%20cord%20that%20immediately%20triggered%20robust%20pressor%20responses.%20The%20system%20durably%20reduced%20the%20severity%20of%20hypotensive%20complications%20in%20people%20with%20SCI%2C%20removed%20the%20necessity%20for%20conservative%20treatments%2C%20improved%20quality%20of%20life%2C%20and%20enabled%20engagement%20in%20activities%20of%20daily%20living.%20Central%20to%20the%20development%20of%20this%20therapy%20was%20the%20head-to-head%20demonstration%20in%20the%20same%20participants%20that%20EES%20must%20target%20the%20last%20three%20thoracic%20segments%2C%20and%20not%20the%20lumbosacral%20segments%2C%20to%20achieve%20the%20safe%20and%20effective%20regulation%20of%20blood%20pressure%20in%20people%20with%20SCI.%20These%20findings%20in%2014%20participants%20establish%20a%20path%20for%20a%20pivotal%20device%20trial%20that%20evaluates%20the%20safety%20and%20efficacy%20of%20EES%20to%20treat%20the%20underappreciated%2C%20treatment-resistant%20hypotensive%20complications%20due%20to%20SCI.%22%2C%22genre%22%3A%22%22%2C%22repository%22%3A%22medRxiv%22%2C%22archiveID%22%3A%22%22%2C%22date%22%3A%222024-11-07%22%2C%22DOI%22%3A%2210.1101%5C%2F2024.05.10.24306826%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.medrxiv.org%5C%2Fcontent%5C%2F10.1101%5C%2F2024.05.10.24306826v3%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A49Z%22%7D%7D%2C%7B%22key%22%3A%2223AWKK4E%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Keesey%20et%20al.%22%2C%22parsedDate%22%3A%222024-07-29%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKeesey%2C%20Rodolfo%2C%20et%20al.%20%26lt%3Bi%26gt%3BFundamental%20Limitations%20of%20Kilohertz-Frequency%20Carriers%20in%20Afferent%20Fiber%20Recruitment%20with%20Transcutaneous%20Spinal%20Cord%20Stimulation%26lt%3B%5C%2Fi%26gt%3B.%20bioRxiv%2C%2029%20July%202024%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2024.07.26.603982%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1101%5C%2F2024.07.26.603982%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22preprint%22%2C%22title%22%3A%22Fundamental%20Limitations%20of%20Kilohertz-Frequency%20Carriers%20in%20Afferent%20Fiber%20Recruitment%20with%20Transcutaneous%20Spinal%20Cord%20Stimulation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rodolfo%22%2C%22lastName%22%3A%22Keesey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ursula%22%2C%22lastName%22%3A%22Hofstoetter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhaoshun%22%2C%22lastName%22%3A%22Hu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lorenzo%22%2C%22lastName%22%3A%22Lombardi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%22%2C%22lastName%22%3A%22Hawthorn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noah%22%2C%22lastName%22%3A%22Bryson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Minassian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ismael%22%2C%22lastName%22%3A%22Se%5Cu00e1%5Cu00f1ez%22%7D%5D%2C%22abstractNote%22%3A%22The%20use%20of%20kilohertz-frequency%20%28KHF%29%20waveforms%20has%20rapidly%20gained%20momentum%20in%20transcutaneous%20spinal%20cord%20stimulation%20%28tSCS%29%20to%20restore%20motor%20function%20after%20paralysis.%20However%2C%20the%20mechanisms%20by%20which%20these%20fast-alternating%20currents%20depolarize%20efferent%20and%20afferent%20fibers%20remain%20unknown.%20Our%20study%20fills%20this%20research%20gap%20by%20providing%20a%20hypothesis-and%20evidence-based%20investigation%20using%20peripheral%20nerve%20stimulation%2C%20lumbar%20tSCS%2C%20and%20cervical%20tSCS%20in%2025%20unimpaired%20participants%20together%20with%20computational%20modeling.%20Peripheral%20nerve%20stimulation%20experiments%20and%20computational%20modeling%20showed%20that%20KHF%20waveforms%20negatively%20impact%20the%20processes%20required%20to%20elicit%20action%20potentials%2C%20thereby%20increasing%20response%20thresholds%20and%20biasing%20the%20recruitment%20towards%20efferent%20fibers.%20While%20these%20results%20translate%20to%20tSCS%2C%20we%20also%20demonstrate%20that%20lumbar%20tSCS%20results%20in%20the%20preferential%20recruitment%20of%20afferent%20fibers%2C%20while%20cervical%20tSCS%20favors%20recruitment%20of%20efferent%20fibers.%20Given%20the%20assumed%20importance%20of%20proprioceptive%20afferents%20in%20motor%20recovery%2C%20our%20work%20suggests%20that%20the%20use%20of%20KHF%20waveforms%20should%20be%20reconsidered%20to%20maximize%20neurorehabilitation%20outcomes%2C%20particularly%20for%20cervical%20tSCS.%20We%20posit%20that%20careful%20analysis%20of%20the%20mechanisms%20that%20mediate%20responses%20elicited%20by%20novel%20approaches%20in%20tSCS%20is%20crucial%20to%20understanding%20their%20potential%20to%20restore%20motor%20function%20after%20paralysis.%22%2C%22genre%22%3A%22%22%2C%22repository%22%3A%22bioRxiv%22%2C%22archiveID%22%3A%22%22%2C%22date%22%3A%222024-07-29%22%2C%22DOI%22%3A%2210.1101%5C%2F2024.07.26.603982%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.biorxiv.org%5C%2Fcontent%5C%2F10.1101%5C%2F2024.07.26.603982v1%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A50Z%22%7D%7D%5D%7D
Phillips, Aaron A., et al. The Implantable System That Restores Hemodynamic Stability after Spinal Cord Injury. medRxiv, 7 Nov. 2024, https://doi.org/10.1101/2024.05.10.24306826.
Keesey, Rodolfo, et al. Fundamental Limitations of Kilohertz-Frequency Carriers in Afferent Fiber Recruitment with Transcutaneous Spinal Cord Stimulation. bioRxiv, 29 July 2024, https://doi.org/10.1101/2024.07.26.603982.
2022
5204873
GWZUDZFB
2022
1
modern-language-association
50
date
desc
84
https://www.pdh.med.fau.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%224HN6RI4N%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Kathe%20et%20al.%22%2C%22parsedDate%22%3A%222022-11%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKathe%2C%20Claudia%2C%20et%20al.%20%26%23x201C%3BThe%20Neurons%20That%20Restore%20Walking%20after%20Paralysis.%26%23x201D%3B%20%26lt%3Bi%26gt%3BNature%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%20611%2C%20no.%207936%2C%20Nov.%202022%2C%20pp.%20540%26%23x2013%3B47%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-022-05385-7%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-022-05385-7%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22The%20neurons%20that%20restore%20walking%20after%20paralysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Kathe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%20A.%22%2C%22lastName%22%3A%22Skinnider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20H.%22%2C%22lastName%22%3A%22Hutson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicola%22%2C%22lastName%22%3A%22Regazzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthieu%22%2C%22lastName%22%3A%22Gautier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Demesmaeker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Salif%22%2C%22lastName%22%3A%22Komi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%22%2C%22lastName%22%3A%22Ceto%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20D.%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Newton%22%2C%22lastName%22%3A%22Cho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laetitia%22%2C%22lastName%22%3A%22Baud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katia%22%2C%22lastName%22%3A%22Galan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaya%20J.%20E.%22%2C%22lastName%22%3A%22Matson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyungjin%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ruijia%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Minassian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%20O.%22%2C%22lastName%22%3A%22Prior%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonie%22%2C%22lastName%22%3A%22Asboth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ariel%20J.%22%2C%22lastName%22%3A%22Levine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordan%20W.%22%2C%22lastName%22%3A%22Squair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22A%20spinal%20cord%20injury%5Cu00a0interrupts%20pathways%20from%20the%20brain%20and%20brainstem%20that%20project%20to%20the%20lumbar%20spinal%20cord%2C%20leading%20to%20paralysis.%20Here%20we%20show%20that%20spatiotemporal%20epidural%20electrical%20stimulation%20%28EES%29%20of%20the%20lumbar%20spinal%20cord1%5Cu20133%20applied%20during%20neurorehabilitation4%2C5%20%28EESREHAB%29%20restored%20walking%20in%20nine%20individuals%20with%20chronic%20spinal%20cord%20injury.%20This%20recovery%20involved%20a%20reduction%20in%20neuronal%20activity%20in%20the%20lumbar%20spinal%20cord%20of%20humans%20during%20walking.%20We%20hypothesized%20that%20this%20unexpected%20reduction%20reflects%20activity-dependent%20selection%20of%20specific%20neuronal%20subpopulations%20that%20become%20essential%20for%20a%20patient%5Cu00a0to%20walk%20after%20spinal%20cord%20injury.%20To%20identify%20these%20putative%20neurons%2C%20we%20modelled%20the%20technological%20and%20therapeutic%20features%20underlying%20EESREHAB%20in%20mice.%20We%20applied%20single-nucleus%20RNA%20sequencing6%5Cu20139%20and%20spatial%20transcriptomics10%2C11%20to%20the%20spinal%20cords%20of%20these%20mice%20to%20chart%20a%20spatially%20resolved%20molecular%20atlas%20of%20recovery%20from%20paralysis.%20We%20then%20employed%5Cu00a0cell%20type12%2C13%20and%20spatial%20prioritization%20to%20identify%20the%20neurons%20involved%20in%20the%20recovery%20of%20walking.%20A%20single%20population%20of%20excitatory%20interneurons%20nested%20within%20intermediate%20laminae%5Cu00a0emerged.%20Although%20these%20neurons%20are%20not%20required%20for%20walking%20before%20spinal%20cord%20injury%2C%20we%20demonstrate%20that%20they%20are%20essential%20for%20the%5Cu00a0recovery%20of%20walking%20with%20EES%20following%20spinal%20cord%20injury.%20Augmenting%20the%20activity%20of%20these%20neurons%20phenocopied%20the%20recovery%20of%20walking%20enabled%20by%20EESREHAB%2C%20whereas%20ablating%20them%20prevented%20the%20recovery%20of%20walking%20that%20occurs%20spontaneously%20after%20moderate%20spinal%20cord%20injury.%20We%20thus%20identified%20a%20recovery-organizing%20neuronal%20subpopulation%20that%20is%20necessary%20and%20sufficient%20to%20regain%20walking%20after%20paralysis.%20Moreover%2C%20our%20methodology%20establishes%20a%20framework%20for%5Cu00a0using%20molecular%20cartography%5Cu00a0to%20identify%20the%20neurons%20that%20produce%20complex%20behaviours.%22%2C%22date%22%3A%222022-11%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41586-022-05385-7%22%2C%22ISSN%22%3A%221476-4687%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41586-022-05385-7%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A49Z%22%7D%7D%2C%7B%22key%22%3A%22R8XCAGYG%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Rowald%20and%20Amft%22%2C%22parsedDate%22%3A%222022-10-31%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BRowald%2C%20Andreas%2C%20and%20Oliver%20Amft.%20%26%23x201C%3BA%20Computational%20Roadmap%20to%20Electronic%20Drugs.%26%23x201D%3B%20%26lt%3Bi%26gt%3BFrontiers%20in%20Neurorobotics%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%2016%2C%20Oct.%202022%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffnbot.2022.983072%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffnbot.2022.983072%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20computational%20roadmap%20to%20electronic%20drugs%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Amft%22%7D%5D%2C%22abstractNote%22%3A%22A%20growing%20number%20of%20complex%20neurostimulation%20strategies%20promise%20symptom%20relief%20and%20functional%20recovery%20for%20several%20neurological%2C%20psychiatric%2C%20and%20even%20multi-organ%20disorders.%20Although%20pharmacological%20interventions%20are%20currently%20the%20mainstay%20of%20treatment%2C%20neurostimulation%20offers%20a%20potentially%20effective%20and%20safe%20alternative%2C%20capable%20of%20providing%20rapid%20adjustment%20to%20short-term%20variation%20and%20long-term%20decline%20of%20physiological%20functions.%20However%2C%20rapid%20advances%20made%20by%20clinical%20studies%20have%20often%20preceded%20the%20fundamental%20understanding%20of%20mechanisms%20underlying%20the%20interactions%20between%20stimulation%20and%20the%20nervous%20system.%20In%20turn%2C%20therapy%20design%20and%20verification%20are%20largely%20driven%20by%20clinical-empirical%20evidence.%20Even%20with%20titanic%20efforts%20and%20budgets%2C%20it%20is%20infeasible%20to%20comprehensively%20explore%20the%20multi-dimensional%20optimization%20space%20of%20neurostimulation%20through%20empirical%20research%20alone%2C%20especially%20since%20anatomical%20structures%20and%20thus%20outcomes%20vary%20dramatically%20between%20patients.%20Instead%2C%20we%20believe%20that%20the%20future%20of%20neurostimulation%20strongly%20depends%20on%20personalizable%20computational%20tools%2C%20i.e.%20Digital%20Neuro%20Twins%20%28DNTs%29%20to%20efficiently%20identify%20effective%20and%20safe%20stimulation%20parameters.%20DNTs%20have%20the%20potential%20to%20accelerate%20scientific%20discovery%20and%20hypothesis-driven%20engineering%2C%20and%20aid%20as%20a%20critical%20regulatory%20and%20clinical%20decision%20support%20tool.%20We%20outline%20here%20how%20DNTs%20will%20pave%20the%20way%20toward%20effective%2C%20cost-%2C%20time-%2C%20and%20risk-limited%20electronic%20drugs%20with%20a%20broad%20application%20bandwidth.%22%2C%22date%22%3A%222022-10-31%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.3389%5C%2Ffnbot.2022.983072%22%2C%22ISSN%22%3A%221662-5218%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Fjournals%5C%2Fneurorobotics%5C%2Farticles%5C%2F10.3389%5C%2Ffnbot.2022.983072%5C%2Ffull%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A48Z%22%7D%7D%2C%7B%22key%22%3A%223XWCKKQ4%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Amunts%20et%20al.%22%2C%22parsedDate%22%3A%222022-03-11%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAmunts%2C%20Katrin%2C%20et%20al.%20%26lt%3Bi%26gt%3BThe%20Coming%20Decade%20of%20Digital%20Brain%20Research%20-%20A%20Vision%20for%20Neuroscience%20at%20the%20Intersection%20of%20Technology%20and%20Computing%26lt%3B%5C%2Fi%26gt%3B.%20Zenodo%2C%2011%20Mar.%202022%2C%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.5281%5C%2Fzenodo.6345821.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22report%22%2C%22title%22%3A%22The%20coming%20decade%20of%20digital%20brain%20research%20-%20A%20vision%20for%20neuroscience%20at%20the%20intersection%20of%20technology%20and%20computing%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katrin%22%2C%22lastName%22%3A%22Amunts%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Axer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lise%22%2C%22lastName%22%3A%22Bitsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Bjaalie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Brovelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Svenja%22%2C%22lastName%22%3A%22Caspers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irene%22%2C%22lastName%22%3A%22Costantini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Egidio%22%2C%22lastName%22%3A%22D%27Angelo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giulia%22%2C%22lastName%22%3A%22De%20Bonis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Javier%22%2C%22lastName%22%3A%22DeFelipe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alain%22%2C%22lastName%22%3A%22Destexhe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Timo%22%2C%22lastName%22%3A%22Dickscheid%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Markus%22%2C%22lastName%22%3A%22Diesmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%20B.%22%2C%22lastName%22%3A%22Eickhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Engel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%22%2C%22lastName%22%3A%22Fousek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stephen%22%2C%22lastName%22%3A%22Furber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rainer%22%2C%22lastName%22%3A%22Goebel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Onur%22%2C%22lastName%22%3A%22G%5Cu00fcnterk%5Cu00fcn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeanette%22%2C%22lastName%22%3A%22Hellgren%20Kotaleski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claus%20C.%22%2C%22lastName%22%3A%22Hilgetag%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%20M.%22%2C%22lastName%22%3A%22H%5Cu00f6lter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannis%22%2C%22lastName%22%3A%22Ioannidis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Viktor%22%2C%22lastName%22%3A%22Jirsa%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wouter%22%2C%22lastName%22%3A%22Klijn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22K%5Cu00e4mpfer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22Lippert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Meyer-Lindenberg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michele%22%2C%22lastName%22%3A%22Migliore%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yannick%22%2C%22lastName%22%3A%22Morel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabrice%22%2C%22lastName%22%3A%22Morin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lena%22%2C%22lastName%22%3A%22Oden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fanis%22%2C%22lastName%22%3A%22Panagiotaropoulos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pier%20Stanislao%22%2C%22lastName%22%3A%22Paolucci%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cyriel%22%2C%22lastName%22%3A%22Pennartz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Spase%22%2C%22lastName%22%3A%22Petkoski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mihai%20A.%22%2C%22lastName%22%3A%22Petrovici%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petra%22%2C%22lastName%22%3A%22Ritter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Rotter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Ruland%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philippe%22%2C%22lastName%22%3A%22Ryvlin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arleen%22%2C%22lastName%22%3A%22Salles%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%20V.%22%2C%22lastName%22%3A%22Sanchez-Vives%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%22%2C%22lastName%22%3A%22Schemmel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Betrand%22%2C%22lastName%22%3A%22Thirion%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wim%22%2C%22lastName%22%3A%22Vanduffel%22%7D%5D%2C%22abstractNote%22%3A%22Brain%20research%20has%20in%20recent%20years%20indisputably%20entered%20a%20new%20epoch%2C%20driven%20by%5Cu00a0substantial%5Cu00a0methodological%5Cu00a0advances%20and%20digitally%5Cu00a0enabled%20data%20integration%20and%20modeling%20at%20multiple%20scales%20%5Cu2013%5Cu00a0from%20molecules%20to%20the%20whole%20system.%20Major%20advances%20are%20emerging%20at%20the%5Cu00a0intersection%20of%20neuroscience%5Cu00a0with%20technology%20and%20computing.%20This%20new%20science%20of%20the%20brain%20integrates%20high-quality%20basic%20research%2C%5Cu00a0systematic%20data%20integration%20across%20multiple%20scales%2C%20a%20new%20culture%20of%20large-scale%20collaboration%20and%5Cu00a0translation%20into%20applications.%20A%20systematic%20approach%2C%20as%20pioneered%20in%20Europe%5Cu2019s%20Human%20Brain%20Project%5Cu00a0%28HBP%29%2C%20will%20be%20essential%20in%20meeting%20the%20pressing%20medical%20and%5Cu00a0technological%20challenges%20of%20the%20coming%5Cu00a0decade.%20The%20aims%20of%20this%20paper%20are%5Cn%5Cn%5Cn%5Cn%5Ct%5CnTo%20develop%20a%20concept%20for%20the%20coming%20decade%20of%20digital%20brain%20research%5Cn%5Ct%5CnTo%20discuss%20it%20with%20the%20research%20community%20at%20large%2C%20with%20the%20aim%20of%20identifying%20points%20of%20convergence%20and%20common%20goals%5Cn%5Ct%5CnTo%20provide%20a%20scientific%20framework%20for%20current%20and%20future%20development%20of%20EBRAINS%5Cn%5Ct%5CnTo%20inform%20and%20engage%20stakeholders%2C%20funding%20organizations%20and%20research%20institutions%20regarding%20future%20digital%20brain%20research%5Cn%5Ct%5CnTo%20identify%20and%20address%20key%20ethical%20and%20societal%20issues%5Cn%5Cn%5Cn%5CnWhile%20we%20do%20not%20claim%20that%20there%20is%20a%20%5Cu2018one%20size%20fits%20all%5Cu2019%20approach%20to%20addressing%20these%20aspects%2C%20we%20are%5Cu00a0convinced%20that%20discussions%20around%20the%20theme%20of%20digital%20brain%20research%20will%20help%20drive%20progress%20in%20the%5Cu00a0broader%20field%20of%20neuroscience.%5Cn%5Cn%5CnComments%20on%20this%20manuscript%20are%20welcome%5Cn%5Cn%5CnThis%20manuscript%5Cu00a0is%20a%20living%20document%20that%20is%20being%20further%20developed%20in%20a%20participatory%20process.%20The%20work%20has%20been%20initiated%20by%20the%20Science%20and%20Infrastructure%20Board%20of%20the%20Human%20Brain%20Project%20%28HBP%29.%20Now%2C%20the%20entire%20research%20community%20is%20invited%20to%20contribute%20to%20shaping%20the%20vision%20by%20submitting%20comments.%5Cu00a0Comments%20can%20be%20submitted%20via%20an%20online%20commentary%20form%20here.%5Cn%5Cn%5CnAll%20submitted%20comments%20will%20be%20considered%20and%20discussed.%20The%20final%20decision%20on%20whether%20edits%20or%20additions%20will%20be%20made%20to%20the%20next%20version%20of%20the%20manuscript%20based%20on%20an%20individual%20comment%20will%20be%20made%20by%20the%20Science%20and%20Infrastructure%20Board%20%28SIB%29%20of%20the%20Human%20Brain%20Project%20%28HBP%29%20at%20regular%20intervals.%5Cn%5Cn%5CnNew%20versions%20of%20the%20manuscript%20will%20be%20published%20every%20few%20months%20on%20Zenodo.%20Comments%20may%20be%20submitted%20until%20the%20beginning%20of%202023.%20During%20the%20Human%20Brain%20Project%20Summit%202023%2C%20the%20manuscript%20will%20be%20adopted%20by%20HBP%20and%20non-HBP%20participants%2C%20and%20a%20final%20version%20will%20be%20published%20shortly%20after.%22%2C%22reportNumber%22%3A%22%22%2C%22reportType%22%3A%22%22%2C%22institution%22%3A%22Zenodo%22%2C%22date%22%3A%222022-03-11%22%2C%22language%22%3A%22eng%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fzenodo.org%5C%2Frecords%5C%2F6345821%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A48Z%22%7D%7D%2C%7B%22key%22%3A%22AUALPBYM%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Kathe%20et%20al.%22%2C%22parsedDate%22%3A%222022-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKathe%2C%20Claudia%2C%20et%20al.%20%26%23x201C%3BWireless%20Closed-Loop%20Optogenetics%20across%20the%20Entire%20Dorsoventral%20Spinal%20Cord%20in%20Mice.%26%23x201D%3B%20%26lt%3Bi%26gt%3BNature%20Biotechnology%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%2040%2C%20no.%202%2C%20Feb.%202022%2C%20pp.%20198%26%23x2013%3B208%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41587-021-01019-x%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41587-021-01019-x%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Wireless%20closed-loop%20optogenetics%20across%20the%20entire%20dorsoventral%20spinal%20cord%20in%20mice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Kathe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fr%5Cu00e9d%5Cu00e9ric%22%2C%22lastName%22%3A%22Michoud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Sch%5Cu00f6nle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22No%5Cu00e9%22%2C%22lastName%22%3A%22Brun%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jimmy%22%2C%22lastName%22%3A%22Ravier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ivan%22%2C%22lastName%22%3A%22Furfaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valentina%22%2C%22lastName%22%3A%22Paggi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kyungjin%22%2C%22lastName%22%3A%22Kim%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sadaf%22%2C%22lastName%22%3A%22Soloukey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonie%22%2C%22lastName%22%3A%22Asboth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20H.%22%2C%22lastName%22%3A%22Hutson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ileana%22%2C%22lastName%22%3A%22Jelescu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antoine%22%2C%22lastName%22%3A%22Philippides%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Noaf%22%2C%22lastName%22%3A%22Alwahab%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00e9r%5Cu00f4me%22%2C%22lastName%22%3A%22Gandar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Daniel%22%2C%22lastName%22%3A%22Huber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%20I.%22%2C%22lastName%22%3A%22De%20Zeeuw%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiuting%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22Optoelectronic%20systems%20can%20exert%20precise%20control%20over%20targeted%20neurons%20and%20pathways%20throughout%20the%20brain%20in%20untethered%20animals%2C%20but%20similar%20technologies%20for%20the%20spinal%20cord%20are%20not%20well%20established.%20In%20the%20present%20study%2C%20we%20describe%20a%20system%20for%20ultrafast%2C%20wireless%2C%20closed-loop%20manipulation%20of%20targeted%20neurons%20and%20pathways%20across%20the%20entire%20dorsoventral%20spinal%20cord%20in%20untethered%20mice.%20We%20developed%20a%20soft%20stretchable%20carrier%2C%20integrating%20microscale%20light-emitting%20diodes%20%28micro-LEDs%29%2C%20that%20conforms%20to%20the%20dura%20mater%20of%20the%20spinal%20cord.%20A%20coating%20of%20silicone%5Cu2013phosphor%20matrix%20over%20the%20micro-LEDs%20provides%20mechanical%20protection%20and%20light%20conversion%20for%20compatibility%20with%20a%20large%20library%20of%20opsins.%20A%20lightweight%2C%20head-mounted%2C%20wireless%20platform%20powers%20the%20micro-LEDs%20and%20performs%20low-latency%2C%20on-chip%20processing%20of%20sensed%20physiological%20signals%20to%20control%20photostimulation%20in%20a%20closed%20loop.%20We%20use%20the%20device%20to%20reveal%20the%20role%20of%20various%20neuronal%20subtypes%2C%20sensory%20pathways%20and%20supraspinal%20projections%20in%20the%20control%20of%20locomotion%20in%20healthy%20and%20spinal-cord%20injured%20mice.%22%2C%22date%22%3A%222022-02%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41587-021-01019-x%22%2C%22ISSN%22%3A%221546-1696%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41587-021-01019-x%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A48Z%22%7D%7D%2C%7B%22key%22%3A%224WI26U7D%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Rowald%20et%20al.%22%2C%22parsedDate%22%3A%222022-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BRowald%2C%20Andreas%2C%20et%20al.%20%26%23x201C%3BActivity-Dependent%20Spinal%20Cord%20Neuromodulation%20Rapidly%20Restores%20Trunk%20and%20Leg%20Motor%20Functions%20after%20Complete%20Paralysis.%26%23x201D%3B%20%26lt%3Bi%26gt%3BNature%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%2028%2C%20no.%202%2C%20Feb.%202022%2C%20pp.%20260%26%23x2013%3B71%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41591-021-01663-5%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41591-021-01663-5%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Activity-dependent%20spinal%20cord%20neuromodulation%20rapidly%20restores%20trunk%20and%20leg%20motor%20functions%20after%20complete%20paralysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Salif%22%2C%22lastName%22%3A%22Komi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Demesmaeker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edeny%22%2C%22lastName%22%3A%22Baaklini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sergio%20Daniel%22%2C%22lastName%22%3A%22Hernandez-Charpak%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edoardo%22%2C%22lastName%22%3A%22Paoles%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hazael%22%2C%22lastName%22%3A%22Montanaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Antonino%22%2C%22lastName%22%3A%22Cassara%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabio%22%2C%22lastName%22%3A%22Becce%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bryn%22%2C%22lastName%22%3A%22Lloyd%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Taylor%22%2C%22lastName%22%3A%22Newton%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jimmy%22%2C%22lastName%22%3A%22Ravier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nawal%22%2C%22lastName%22%3A%22Kinany%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marina%22%2C%22lastName%22%3A%22D%5Cu2019Ercole%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aur%5Cu00e9lie%22%2C%22lastName%22%3A%22Paley%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Hankov%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%22%2C%22lastName%22%3A%22Varescon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22McCracken%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Molywan%22%2C%22lastName%22%3A%22Vat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miroslav%22%2C%22lastName%22%3A%22Caban%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Watrin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Jacquet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22L%5Cu00e9a%22%2C%22lastName%22%3A%22Bole-Feysot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cathal%22%2C%22lastName%22%3A%22Harte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henri%22%2C%22lastName%22%3A%22Lorach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrea%22%2C%22lastName%22%3A%22Galvez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manon%22%2C%22lastName%22%3A%22Tschopp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Natacha%22%2C%22lastName%22%3A%22Herrmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mo%5Cu00efra%22%2C%22lastName%22%3A%22Wacker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22Geernaert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Fodor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Valentin%22%2C%22lastName%22%3A%22Radevich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katrien%22%2C%22lastName%22%3A%22Van%20Den%20Keybus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Eberle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Etienne%22%2C%22lastName%22%3A%22Pralong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maxime%22%2C%22lastName%22%3A%22Roulet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Baptiste%22%2C%22lastName%22%3A%22Ledoux%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eleonora%22%2C%22lastName%22%3A%22Fornari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22Mandija%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Loan%22%2C%22lastName%22%3A%22Mattera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roberto%22%2C%22lastName%22%3A%22Martuzzi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bruno%22%2C%22lastName%22%3A%22Nazarian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Benkler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simone%22%2C%22lastName%22%3A%22Callegari%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nathan%22%2C%22lastName%22%3A%22Greiner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benjamin%22%2C%22lastName%22%3A%22Fuhrer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martijn%22%2C%22lastName%22%3A%22Froeling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nik%22%2C%22lastName%22%3A%22Buse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tim%22%2C%22lastName%22%3A%22Denison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rik%22%2C%22lastName%22%3A%22Buschman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Wende%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Damien%22%2C%22lastName%22%3A%22Ganty%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jurriaan%22%2C%22lastName%22%3A%22Bakker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Delattre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hendrik%22%2C%22lastName%22%3A%22Lambert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Minassian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelis%20A.%20T.%22%2C%22lastName%22%3A%22van%20den%20Berg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Kavounoudias%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvestro%22%2C%22lastName%22%3A%22Micera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dimitri%22%2C%22lastName%22%3A%22Van%20De%20Ville%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erkan%22%2C%22lastName%22%3A%22Kurt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niels%22%2C%22lastName%22%3A%22Kuster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esra%22%2C%22lastName%22%3A%22Neufeld%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Capogrosso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonie%22%2C%22lastName%22%3A%22Asboth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%20B.%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22Epidural%20electrical%20stimulation%20%28EES%29%20targeting%20the%20dorsal%20roots%20of%20lumbosacral%20segments%20restores%20walking%20in%20people%20with%20spinal%20cord%20injury%20%28SCI%29.%20However%2C%20EES%20is%20delivered%20with%20multielectrode%20paddle%20leads%20that%20were%20originally%20designed%20to%20target%20the%20dorsal%20column%20of%20the%20spinal%20cord.%20Here%2C%20we%20hypothesized%20that%20an%20arrangement%20of%20electrodes%20targeting%20the%20ensemble%20of%20dorsal%20roots%20involved%20in%20leg%20and%20trunk%20movements%20would%20result%20in%20superior%20efficacy%2C%20restoring%20more%20diverse%20motor%20activities%20after%20the%20most%20severe%20SCI.%20To%20test%20this%20hypothesis%2C%20we%20established%20a%20computational%20framework%20that%20informed%20the%20optimal%20arrangement%20of%20electrodes%20on%20a%20new%20paddle%20lead%20and%20guided%20its%20neurosurgical%20positioning.%20We%20also%20developed%20software%20supporting%20the%20rapid%20configuration%20of%20activity-specific%20stimulation%20programs%20that%20reproduced%20the%20natural%20activation%20of%20motor%20neurons%20underlying%20each%20activity.%20We%20tested%20these%20neurotechnologies%20in%20three%20individuals%20with%20complete%20sensorimotor%20paralysis%20as%20part%20of%20an%20ongoing%20clinical%20trial%20%28www.clinicaltrials.govidentifier%20NCT02936453%29.%20Within%20a%20single%20day%2C%20activity-specific%20stimulation%20programs%20enabled%20these%20three%20individuals%20to%20stand%2C%20walk%2C%20cycle%2C%20swim%20and%20control%20trunk%20movements.%20Neurorehabilitation%20mediated%20sufficient%20improvement%20to%20restore%20these%20activities%20in%20community%20settings%2C%20opening%20a%20realistic%20path%20to%20support%20everyday%20mobility%20with%20EES%20in%20people%20with%20SCI.%22%2C%22date%22%3A%222022-02%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41591-021-01663-5%22%2C%22ISSN%22%3A%221546-170X%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41591-021-01663-5%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A48Z%22%7D%7D%5D%7D
Kathe, Claudia, et al. “The Neurons That Restore Walking after Paralysis.” Nature, vol. 611, no. 7936, Nov. 2022, pp. 540–47, https://doi.org/10.1038/s41586-022-05385-7.
Rowald, Andreas, and Oliver Amft. “A Computational Roadmap to Electronic Drugs.” Frontiers in Neurorobotics, vol. 16, Oct. 2022, https://doi.org/10.3389/fnbot.2022.983072.
Amunts, Katrin, et al. The Coming Decade of Digital Brain Research - A Vision for Neuroscience at the Intersection of Technology and Computing. Zenodo, 11 Mar. 2022, https://doi.org/10.5281/zenodo.6345821.
Kathe, Claudia, et al. “Wireless Closed-Loop Optogenetics across the Entire Dorsoventral Spinal Cord in Mice.” Nature Biotechnology, vol. 40, no. 2, Feb. 2022, pp. 198–208, https://doi.org/10.1038/s41587-021-01019-x.
Rowald, Andreas, et al. “Activity-Dependent Spinal Cord Neuromodulation Rapidly Restores Trunk and Leg Motor Functions after Complete Paralysis.” Nature Medicine, vol. 28, no. 2, Feb. 2022, pp. 260–71, https://doi.org/10.1038/s41591-021-01663-5.
2021
5204873
GWZUDZFB
2021
1
modern-language-association
50
date
desc
84
https://www.pdh.med.fau.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22ZR9VSM8S%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Squair%20et%20al.%22%2C%22parsedDate%22%3A%222021-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSquair%2C%20Jordan%20W.%2C%20et%20al.%20%26%23x201C%3BNeuroprosthetic%20Baroreflex%20Controls%20Haemodynamics%20after%20Spinal%20Cord%20Injury.%26%23x201D%3B%20%26lt%3Bi%26gt%3BNature%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%20590%2C%20no.%207845%2C%20Feb.%202021%2C%20pp.%20308%26%23x2013%3B14%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-020-03180-w%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-020-03180-w%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Neuroprosthetic%20baroreflex%20controls%20haemodynamics%20after%20spinal%20cord%20injury%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jordan%20W.%22%2C%22lastName%22%3A%22Squair%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthieu%22%2C%22lastName%22%3A%22Gautier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lois%22%2C%22lastName%22%3A%22Mahe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20Elaine%22%2C%22lastName%22%3A%22Soriano%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Arnaud%22%2C%22lastName%22%3A%22Bichat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Newton%22%2C%22lastName%22%3A%22Cho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mark%20A.%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%20D.%22%2C%22lastName%22%3A%22James%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jerome%22%2C%22lastName%22%3A%22Gandar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anthony%20V.%22%2C%22lastName%22%3A%22Incognito%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giuseppe%22%2C%22lastName%22%3A%22Schiavone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zoe%20K.%22%2C%22lastName%22%3A%22Sarafis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Achilleas%22%2C%22lastName%22%3A%22Laskaratos%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kay%22%2C%22lastName%22%3A%22Bartholdi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Demesmaeker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Salif%22%2C%22lastName%22%3A%22Komi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charlotte%22%2C%22lastName%22%3A%22Moerman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bita%22%2C%22lastName%22%3A%22Vaseghi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Berkeley%22%2C%22lastName%22%3A%22Scott%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ryan%22%2C%22lastName%22%3A%22Rosentreter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Kathe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jimmy%22%2C%22lastName%22%3A%22Ravier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22McCracken%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoyang%22%2C%22lastName%22%3A%22Kang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Vachicouras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Fallegger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ileana%22%2C%22lastName%22%3A%22Jelescu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22YunLong%22%2C%22lastName%22%3A%22Cheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qin%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rik%22%2C%22lastName%22%3A%22Buschman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Buse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tim%22%2C%22lastName%22%3A%22Denison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sean%22%2C%22lastName%22%3A%22Dukelow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rebecca%22%2C%22lastName%22%3A%22Charbonneau%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ian%22%2C%22lastName%22%3A%22Rigby%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Steven%20K.%22%2C%22lastName%22%3A%22Boyd%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philip%20J.%22%2C%22lastName%22%3A%22Millar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eduardo%20Martin%22%2C%22lastName%22%3A%22Moraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Capogrosso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%20B.%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Quentin%22%2C%22lastName%22%3A%22Barraud%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erwan%22%2C%22lastName%22%3A%22Bezard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aaron%20A.%22%2C%22lastName%22%3A%22Phillips%22%7D%5D%2C%22abstractNote%22%3A%22Spinal%20cord%20injury%20%28SCI%29%20induces%20haemodynamic%20instability%20that%20threatens%20survival1%5Cu20133%2C%20impairs%20neurological%20recovery4%2C5%2C%20increases%20the%20risk%20of%20cardiovascular%20disease6%2C7%2C%20and%20reduces%20quality%20of%20life8%2C9.%20Haemodynamic%20instability%20in%20this%20context%20is%20due%20to%20the%20interruption%20of%20supraspinal%20efferent%20commands%20to%20sympathetic%20circuits%20located%20in%20the%20spinal%20cord10%2C%20which%20prevents%20the%20natural%20baroreflex%20from%20controlling%20these%20circuits%20to%20adjust%20peripheral%20vascular%20resistance.%20Epidural%20electrical%20stimulation%20%28EES%29%20of%20the%20spinal%20cord%20has%20been%20shown%20to%20compensate%20for%20interrupted%20supraspinal%20commands%20to%20motor%20circuits%20below%20the%20injury11%2C%20and%20restored%20walking%20after%20paralysis12.%20Here%2C%20we%20leveraged%20these%20concepts%20to%20develop%20EES%20protocols%20that%20restored%20haemodynamic%20stability%20after%20SCI.%20We%20established%20a%20preclinical%20model%20that%20enabled%20us%20to%20dissect%20the%20topology%20and%20dynamics%20of%20the%20sympathetic%20circuits%2C%20and%20to%20understand%20how%20EES%20can%20engage%20these%20circuits.%20We%20incorporated%20these%20spatial%20and%20temporal%20features%20into%20stimulation%20protocols%20to%20conceive%20a%20clinical-grade%20biomimetic%20haemodynamic%20regulator%20that%20operates%20in%20a%20closed%20loop.%20This%20%5Cu2018neuroprosthetic%20baroreflex%5Cu2019%20controlled%20haemodynamics%20for%20extended%20periods%20of%20time%20in%20rodents%2C%20non-human%20primates%20and%20humans%2C%20after%20both%20acute%20and%20chronic%20SCI.%20We%20will%20now%20conduct%20clinical%20trials%20to%20turn%20the%20neuroprosthetic%20baroreflex%20into%20a%20commonly%20available%20therapy%20for%20people%20with%20SCI.%22%2C%22date%22%3A%222021-02%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41586-020-03180-w%22%2C%22ISSN%22%3A%221476-4687%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41586-020-03180-w%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A47Z%22%7D%7D%5D%7D
Squair, Jordan W., et al. “Neuroprosthetic Baroreflex Controls Haemodynamics after Spinal Cord Injury.” Nature, vol. 590, no. 7845, Feb. 2021, pp. 308–14, https://doi.org/10.1038/s41586-020-03180-w.
2020
5204873
GWZUDZFB
2020
1
modern-language-association
50
date
desc
84
https://www.pdh.med.fau.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22WIGR5UPQ%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Schiavone%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSchiavone%2C%20Giuseppe%2C%20et%20al.%20%26%23x201C%3BSoft%2C%20Implantable%20Bioelectronic%20Interfaces%20for%20Translational%20Research.%26%23x201D%3B%20%26lt%3Bi%26gt%3BAdvanced%20Materials%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%2032%2C%20no.%2017%2C%202020%2C%20p.%201906512%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadma.201906512%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fadma.201906512%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Soft%2C%20Implantable%20Bioelectronic%20Interfaces%20for%20Translational%20Research%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Giuseppe%22%2C%22lastName%22%3A%22Schiavone%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Fallegger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoyang%22%2C%22lastName%22%3A%22Kang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beatrice%22%2C%22lastName%22%3A%22Barra%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicolas%22%2C%22lastName%22%3A%22Vachicouras%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Evgenia%22%2C%22lastName%22%3A%22Roussinova%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ivan%22%2C%22lastName%22%3A%22Furfaro%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S%5Cu00e9bastien%22%2C%22lastName%22%3A%22Jiguet%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ismael%22%2C%22lastName%22%3A%22Se%5Cu00e1%5Cu00f1ez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Simon%22%2C%22lastName%22%3A%22Borgognon%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qin%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chuan%22%2C%22lastName%22%3A%22Qin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erwan%22%2C%22lastName%22%3A%22B%5Cu00e9zard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Capogrosso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22St%5Cu00e9phanie%20P.%22%2C%22lastName%22%3A%22Lacour%22%7D%5D%2C%22abstractNote%22%3A%22The%20convergence%20of%20materials%20science%2C%20electronics%2C%20and%20biology%2C%20namely%20bioelectronic%20interfaces%2C%20leads%20novel%20and%20precise%20communication%20with%20biological%20tissue%2C%20particularly%20with%20the%20nervous%20system.%20However%2C%20the%20translation%20of%20lab-based%20innovation%20toward%20clinical%20use%20calls%20for%20further%20advances%20in%20materials%2C%20manufacturing%20and%20characterization%20paradigms%2C%20and%20design%20rules.%20Herein%2C%20a%20translational%20framework%20engineered%20to%20accelerate%20the%20deployment%20of%20microfabricated%20interfaces%20for%20translational%20research%20is%20proposed%20and%20applied%20to%20the%20soft%20neurotechnology%20called%20electronic%20dura%20mater%2C%20e-dura.%20Anatomy%2C%20implant%20function%2C%20and%20surgical%20procedure%20guide%20the%20system%20design.%20A%20high-yield%2C%20silicone-on-silicon%20wafer%20process%20is%20developed%20to%20ensure%20reproducible%20characteristics%20of%20the%20electrodes.%20A%20biomimetic%20multimodal%20platform%20that%20replicates%20surgical%20insertion%20in%20an%20anatomy-based%20model%20applies%20physiological%20movement%2C%20emulates%20therapeutic%20use%20of%20the%20electrodes%2C%20and%20enables%20advanced%20validation%20and%20rapid%20optimization%20in%20vitro%20of%20the%20implants.%20Functionality%20of%20scaled%20e-dura%20is%20confirmed%20in%20nonhuman%20primates%2C%20where%20epidural%20neuromodulation%20of%20the%20spinal%20cord%20activates%20selective%20groups%20of%20muscles%20in%20the%20upper%20limbs%20with%20unmet%20precision.%20Performance%20stability%20is%20controlled%20over%206%20weeks%20in%20vivo.%20The%20synergistic%20steps%20of%20design%2C%20fabrication%2C%20and%20biomimetic%20in%20vitro%20validation%20and%20in%20vivo%20evaluation%20in%20translational%20animal%20models%20are%20of%20general%20applicability%20and%20answer%20needs%20in%20multiple%20bioelectronic%20designs%20and%20medical%20technologies.%22%2C%22date%22%3A%222020%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1002%5C%2Fadma.201906512%22%2C%22ISSN%22%3A%221521-4095%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1002%5C%2Fadma.201906512%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A46Z%22%7D%7D%5D%7D
Schiavone, Giuseppe, et al. “Soft, Implantable Bioelectronic Interfaces for Translational Research.” Advanced Materials, vol. 32, no. 17, 2020, p. 1906512, https://doi.org/10.1002/adma.201906512.
2019
5204873
GWZUDZFB
2019
1
modern-language-association
50
date
desc
84
https://www.pdh.med.fau.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22CJ4XY4VV%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Mandija%20et%20al.%22%2C%22parsedDate%22%3A%222019%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMandija%2C%20Stefano%2C%20et%20al.%20%26%23x201C%3BLarge%20Field-of-View%20High%20Resolution%203D%20Imaging%20of%20the%20Thoracolumbar%20Nerve%20Roots%20inside%20the%20Spinal%20Canal.%26%23x201D%3B%20%26lt%3Bi%26gt%3BLarge%20Field-of-View%20High%20Resolution%203D%20Imaging%20of%20the%20Thoracolumbar%20Nerve%20Roots%20inside%20the%20Spinal%20Canal%26lt%3B%5C%2Fi%26gt%3B%2C%202019%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Farchive.ismrm.org%5C%2F2019%5C%2F2883.html%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Farchive.ismrm.org%5C%2F2019%5C%2F2883.html%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22webpage%22%2C%22title%22%3A%22Large%20field-of-view%20high%20resolution%203D%20imaging%20of%20the%20thoracolumbar%20nerve%20roots%20inside%20the%20spinal%20canal%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22Mandija%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martijn%22%2C%22lastName%22%3A%22Froeling%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22G.%20van%20der%20Kolk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fredy%22%2C%22lastName%22%3A%22Visser%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222019%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Farchive.ismrm.org%5C%2F2019%5C%2F2883.html%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A46Z%22%7D%7D%5D%7D
Mandija, Stefano, et al. “Large Field-of-View High Resolution 3D Imaging of the Thoracolumbar Nerve Roots inside the Spinal Canal.” Large Field-of-View High Resolution 3D Imaging of the Thoracolumbar Nerve Roots inside the Spinal Canal, 2019, https://archive.ismrm.org/2019/2883.html.
2018
5204873
GWZUDZFB
2018
1
modern-language-association
50
date
desc
84
https://www.pdh.med.fau.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%227ER6Y2WD%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Formento%20et%20al.%22%2C%22parsedDate%22%3A%222018-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFormento%2C%20Emanuele%2C%20et%20al.%20%26%23x201C%3BElectrical%20Spinal%20Cord%20Stimulation%20Must%20Preserve%20Proprioception%20to%20Enable%20Locomotion%20in%20Humans%20with%20Spinal%20Cord%20Injury.%26%23x201D%3B%20%26lt%3Bi%26gt%3BNature%20Neuroscience%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%2021%2C%20no.%2012%2C%20Dec.%202018%2C%20pp.%201728%26%23x2013%3B41%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41593-018-0262-6%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41593-018-0262-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Electrical%20spinal%20cord%20stimulation%20must%20preserve%20proprioception%20to%20enable%20locomotion%20in%20humans%20with%20spinal%20cord%20injury%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emanuele%22%2C%22lastName%22%3A%22Formento%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Minassian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean%20Baptiste%22%2C%22lastName%22%3A%22Mignardot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%20G.%22%2C%22lastName%22%3A%22Le%20Goff-Mignardot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silvestro%22%2C%22lastName%22%3A%22Micera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Capogrosso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gregoire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22Epidural%20electrical%20stimulation%20%28EES%29%20of%20the%20spinal%20cord%20restores%20locomotion%20in%20animal%20models%20of%20spinal%20cord%20injury%20but%20is%20less%20effective%20in%20humans.%20Here%20we%20hypothesized%20that%20this%20interspecies%20discrepancy%20is%20due%20to%20interference%20between%20EES%20and%20proprioceptive%20information%20in%20humans.%20Computational%20simulations%20and%20preclinical%20and%20clinical%20experiments%20reveal%20that%20EES%20blocks%20a%20significant%20amount%20of%20proprioceptive%20input%20in%20humans%2C%20but%20not%20in%20rats.%20This%20transient%20deafferentation%20prevents%20modulation%20of%20reciprocal%20inhibitory%20networks%20involved%20in%20locomotion%20and%20reduces%20or%20abolishes%20the%20conscious%20perception%20of%20leg%20position.%20Consequently%2C%20continuous%20EES%20can%20only%20facilitate%20locomotion%20within%20a%20narrow%20range%20of%20stimulation%20parameters%20and%20is%20unable%20to%20provide%20meaningful%20locomotor%20improvements%20in%20humans%20without%20rehabilitation.%20Simulations%20showed%20that%20burst%20stimulation%20and%20spatiotemporal%20stimulation%20profiles%20mitigate%20the%20cancellation%20of%20proprioceptive%20information%2C%20enabling%20robust%20control%20over%20motor%20neuron%20activity.%20This%20demonstrates%20the%20importance%20of%20stimulation%20protocols%20that%20preserve%20proprioceptive%20information%20to%20facilitate%20walking%20with%20EES.%22%2C%22date%22%3A%222018-12%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41593-018-0262-6%22%2C%22ISSN%22%3A%221546-1726%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41593-018-0262-6%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A46Z%22%7D%7D%2C%7B%22key%22%3A%22US3MWTLK%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Wagner%20et%20al.%22%2C%22parsedDate%22%3A%222018-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWagner%2C%20Fabien%20B.%2C%20et%20al.%20%26%23x201C%3BTargeted%20Neurotechnology%20Restores%20Walking%20in%20Humans%20with%20Spinal%20Cord%20Injury.%26%23x201D%3B%20%26lt%3Bi%26gt%3BNature%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%20563%2C%20no.%207729%2C%20Nov.%202018%2C%20pp.%2065%26%23x2013%3B71%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-018-0649-2%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41586-018-0649-2%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Targeted%20neurotechnology%20restores%20walking%20in%20humans%20with%20spinal%20cord%20injury%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabien%20B.%22%2C%22lastName%22%3A%22Wagner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Baptiste%22%2C%22lastName%22%3A%22Mignardot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Camille%20G.%22%2C%22lastName%22%3A%22Le%20Goff-Mignardot%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robin%22%2C%22lastName%22%3A%22Demesmaeker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Salif%22%2C%22lastName%22%3A%22Komi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marco%22%2C%22lastName%22%3A%22Capogrosso%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ismael%22%2C%22lastName%22%3A%22Se%5Cu00e1%5Cu00f1ez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miroslav%22%2C%22lastName%22%3A%22Caban%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Elvira%22%2C%22lastName%22%3A%22Pirondini%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Molywan%22%2C%22lastName%22%3A%22Vat%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%20A.%22%2C%22lastName%22%3A%22McCracken%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Roman%22%2C%22lastName%22%3A%22Heimgartner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Fodor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Watrin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Perrine%22%2C%22lastName%22%3A%22Seguin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edoardo%22%2C%22lastName%22%3A%22Paoles%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katrien%22%2C%22lastName%22%3A%22Van%20Den%20Keybus%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Eberle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Brigitte%22%2C%22lastName%22%3A%22Schurch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Etienne%22%2C%22lastName%22%3A%22Pralong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fabio%22%2C%22lastName%22%3A%22Becce%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22John%22%2C%22lastName%22%3A%22Prior%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicholas%22%2C%22lastName%22%3A%22Buse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rik%22%2C%22lastName%22%3A%22Buschman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Esra%22%2C%22lastName%22%3A%22Neufeld%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Niels%22%2C%22lastName%22%3A%22Kuster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefano%22%2C%22lastName%22%3A%22Carda%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joachim%22%2C%22lastName%22%3A%22von%20Zitzewitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vincent%22%2C%22lastName%22%3A%22Delattre%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tim%22%2C%22lastName%22%3A%22Denison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hendrik%22%2C%22lastName%22%3A%22Lambert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karen%22%2C%22lastName%22%3A%22Minassian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jocelyne%22%2C%22lastName%22%3A%22Bloch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gr%5Cu00e9goire%22%2C%22lastName%22%3A%22Courtine%22%7D%5D%2C%22abstractNote%22%3A%22Spinal%20cord%20injury%20leads%20to%20severe%20locomotor%20deficits%20or%20even%20complete%20leg%20paralysis.%20Here%20we%20introduce%20targeted%20spinal%20cord%20stimulation%20neurotechnologies%20that%20enabled%20voluntary%20control%20of%20walking%20in%20individuals%20who%20had%20sustained%20a%20spinal%20cord%20injury%20more%20than%20four%20years%20ago%20and%20presented%20with%20permanent%20motor%20deficits%20or%20complete%20paralysis%20despite%20extensive%20rehabilitation.%20Using%20an%20implanted%20pulse%20generator%20with%20real-time%20triggering%20capabilities%2C%20we%20delivered%20trains%20of%20spatially%20selective%20stimulation%20to%20the%20lumbosacral%20spinal%20cord%20with%20timing%20that%20coincided%20with%20the%20intended%20movement.%20Within%20one%20week%2C%20this%20spatiotemporal%20stimulation%20had%20re-established%20adaptive%20control%20of%20paralysed%20muscles%20during%20overground%20walking.%20Locomotor%20performance%20improved%20during%20rehabilitation.%20After%20a%20few%20months%2C%20participants%20regained%20voluntary%20control%20over%20previously%20paralysed%20muscles%20without%20stimulation%20and%20could%20walk%20or%20cycle%20in%20ecological%20settings%20during%20spatiotemporal%20stimulation.%20These%20results%20establish%20a%20technological%20framework%20for%20improving%20neurological%20recovery%20and%20supporting%20the%20activities%20of%20daily%20living%20after%20spinal%20cord%20injury.%22%2C%22date%22%3A%222018-11%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41586-018-0649-2%22%2C%22ISSN%22%3A%221476-4687%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41586-018-0649-2%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A46Z%22%7D%7D%5D%7D
Formento, Emanuele, et al. “Electrical Spinal Cord Stimulation Must Preserve Proprioception to Enable Locomotion in Humans with Spinal Cord Injury.” Nature Neuroscience, vol. 21, no. 12, Dec. 2018, pp. 1728–41, https://doi.org/10.1038/s41593-018-0262-6.
Wagner, Fabien B., et al. “Targeted Neurotechnology Restores Walking in Humans with Spinal Cord Injury.” Nature, vol. 563, no. 7729, Nov. 2018, pp. 65–71, https://doi.org/10.1038/s41586-018-0649-2.
2016
5204873
GWZUDZFB
2016
1
modern-language-association
50
date
desc
84
https://www.pdh.med.fau.de/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22ZXDLM5T9%22%2C%22library%22%3A%7B%22id%22%3A5204873%7D%2C%22meta%22%3A%7B%22lastModifiedByUser%22%3A%7B%22id%22%3A8815190%2C%22username%22%3A%22OneWorldOneLife%22%2C%22name%22%3A%22Markus%20Deglmann%22%2C%22links%22%3A%7B%22alternate%22%3A%7B%22href%22%3A%22https%3A%5C%2F%5C%2Fwww.zotero.org%5C%2Foneworldonelife%22%2C%22type%22%3A%22text%5C%2Fhtml%22%7D%7D%7D%2C%22creatorSummary%22%3A%22Deschamps%20et%20al.%22%2C%22parsedDate%22%3A%222016-11-28%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDeschamps%2C%20Joran%2C%20et%20al.%20%26%23x201C%3BEfficient%20Homogeneous%20Illumination%20and%20Optical%20Sectioning%20for%20Quantitative%20Single-Molecule%20Localization%20Microscopy.%26%23x201D%3B%20%26lt%3Bi%26gt%3BOptics%20Express%26lt%3B%5C%2Fi%26gt%3B%2C%20vol.%2024%2C%20no.%2024%2C%20Nov.%202016%2C%20pp.%2028080%26%23x2013%3B90%2C%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1364%5C%2FOE.24.028080%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1364%5C%2FOE.24.028080%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Efficient%20homogeneous%20illumination%20and%20optical%20sectioning%20for%20quantitative%20single-molecule%20localization%20microscopy%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joran%22%2C%22lastName%22%3A%22Deschamps%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Rowald%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonas%22%2C%22lastName%22%3A%22Ries%22%7D%5D%2C%22abstractNote%22%3A%22Single-molecule%20localization%20microscopy%20%28SMLM%29%20relies%20on%20the%20switching%20of%20fluorescent%20molecules%20between%20a%20fluorescent%20and%20a%20dark%20state%20to%20achieve%20super%20resolution.%20This%20process%20is%20inherently%20dependent%20on%20the%20intensity%20distribution%20of%20the%20laser%20light%20used%20for%20both%20activation%20from%20the%20dark%20state%20and%20excitation%20of%20the%20bright%20state.%20Typically%2C%20laser%20light%20is%20coupled%20directly%20or%20via%20a%20single-mode%20fiber%20into%20the%20microscope%2C%20which%20leads%20to%20a%20Gaussian%20intensity%20profile%20in%20total%20internal%20reflection%20%28TIR%29%20or%20epi%20illumination.%20As%20a%20result%2C%20switching%20dynamics%20and%20brightness%20of%20the%20fluorescent%20molecules%20vary%20strongly%20across%20the%20field%20of%20view%2C%20impacting%20their%20localization%20precision%20and%20impeding%20quantitative%20analysis.%20Here%20we%20present%20a%20simple%20illumination%20scheme%20based%20on%20the%20use%20of%20a%20multimode%20fiber%20and%20a%20laser%20speckle-reducer%2C%20which%20results%20in%20a%20flat%2C%20homogeneous%20and%20speckle-free%20illumination%20across%20the%20entire%20field%20of%20view.%20In%20addition%2C%20we%20combined%20homogeneous%20multimode%20excitation%20of%20the%20sample%20with%20single-mode%20based%20TIR%20activation%20to%20simultaneously%20obtain%20the%20advantages%20of%20both%20approaches%3A%20uniform%20brightness%20of%20single%20fluorophores%20and%20TIR-like%20optical%20sectioning.%22%2C%22date%22%3A%222016%5C%2F11%5C%2F28%22%2C%22language%22%3A%22EN%22%2C%22DOI%22%3A%2210.1364%5C%2FOE.24.028080%22%2C%22ISSN%22%3A%221094-4087%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fopg.optica.org%5C%2Foe%5C%2Fabstract.cfm%3Furi%3Doe-24-24-28080%22%2C%22collections%22%3A%5B%22GWZUDZFB%22%5D%2C%22dateModified%22%3A%222025-07-07T13%3A29%3A46Z%22%7D%7D%5D%7D
Deschamps, Joran, et al. “Efficient Homogeneous Illumination and Optical Sectioning for Quantitative Single-Molecule Localization Microscopy.” Optics Express, vol. 24, no. 24, Nov. 2016, pp. 28080–90, https://doi.org/10.1364/OE.24.028080.
First Published on September 22, 2024
Last Updated on July 7, 2025 by Zhaoshun Hu