Lumbosacral Epidural Spinal Cord Stimulation

Spinal cord stimulation (SCS) applied over the epidural space of the lumbosacral spinal cord facilitates lower limb motor function after paralysis. Several technologies have been proposed. Various technologies have been developed, with targeted eSCS achieving notable outcomes by selectively stimulating afferent fibers in specific dorsal roots linked to individual motor functions. However, targeting specific dorsal roots remains challenging due to significant inter-individual variability in anatomical parameters across diverse patient populations.

We apply our multi-scale digital twin and neurostimulation optimization methods to:

1. Optimize eSCS therapy design and clinical decision-making to enhance treatment efficacy and patient outcomes.
2. Validate neural axon models against electrophysiological data to deepen understanding of the microanatomy involved in eSCS.
3. Explore electrode positioning and its impact on the activation of different neural structures, such as somatosensory fibers in dorsal roots, ventral root fibers, and fibers in the dorsal columns.
4. Assess current neurostimulation solutions to identify the most suitable approaches for specific clinical scenarios.